2021 Mercedes-Benz S-Class vs 2022 Nissan Altima

2021 Mercedes-Benz S-Class
2021 Mercedes-Benz S-Class
$109,800MSRP
Overview
Overview
OverviewShop Now
2022 Nissan Altima
2022 Nissan Altima
$24,900MSRP
Overview
Overview
OverviewShop Now
2021 Mercedes-Benz S-Class
$109,800MSRP
Overview
Overview
OverviewShop Now
2022 Nissan Altima
$24,900MSRP
Overview
Overview
OverviewShop Now

Overview

MSRP

$109,800

MSRP

$24,900

Listings

262

Listings

2464

Ratings & Reviews

User Reviews
User Reviews

Expert reviews

7.5 out of 10

Expert reviews

7.5 out of 10
Pros
  • Powerful engine
  • Comfortable
  • Impressive technology
Cons
  • High price
Pros
  • Multiple powertrain options
  • Stylish design
  • Standard advanced safety features
Cons
  • Underwhelming base engine
  • All-wheel drive not available with VC-Turbo engine
  • No hybrid option

2021 Mercedes-Benz S-Class Reviews Summary

The S-Class not only sits at the top of the Mercedes hierarchy in price and prestige, but it has also long served as a technological showcase. In the press release for the redesigned 2021 S-Class, Mercedes repeatedly noted the innovations—from anti-lock brakes to airbags—that were introduced on the big sedan and eventually trickled down to mainstream vehicles.

With the previous generation dating back to the 2014 model year (with a significant update for 2018), the Mercedes-Benz S-Class was in need of an update to maintain that status, and to keep pace with other full-size luxury sedans like the Audi A8, BMW 7 Series, and Lexus LS. To do that, the new S-Class gets a more sophisticated infotainment system, new powertrains, and more aerodynamic bodywork, among other features.

The 2021 S-Class launches in two configurations, both with 4Matic all-wheel drive (AWD) and EQ Boost mild-hybrid systems. The S500 4Matic has a six-cylinder engine, while the S580 4Matic has a V8. We spent a few days with the Mercedes-Benz S580 for this review. A Mercedes-Maybach S680 4Matic version will follow in the first half of 2022, and you can expect a new AMG performance version sometime in the future as well.

2022 Nissan Altima Reviews Summary

The Nissan Altima offers buyers a wide range of choices with two engines, front-wheel drive (FWD) or all-wheel drive (AWD), and five trim levels. But in a crowded midsize sedan segment that includes the ubiquitous Toyota Camry and the Honda Accord—not to mention a handful of other competent entries—the Altima has its work cut out for it. For 2022, Nissan tweaks the Altima's packaging, expanding the availability of the sporty Midnight Edition option package to include the SR trim with the base 2.5-liter four-cylinder engine.
No video found

Popular Features & Specs

Engine

3.0L 429 hp I6

Engine

2.5L 188 hp I4

Drive Train

AWD

Drive Train

FWD

Seating Capacity

5

Seating Capacity

5

Horsepower

429 hp @ 6100 rpm

Horsepower

188 hp @ 6000 rpm

MPG City

20

MPG City

28

MPG Highway

29

MPG Highway

39
2021 Mercedes-Benz S-Class
2021 Mercedes-Benz S-Class
$109,800MSRP
Overview
Overview
OverviewShop Now
2022 Nissan Altima
2022 Nissan Altima
$24,900MSRP
Overview
Overview
OverviewShop Now
2021 Mercedes-Benz S-Class
$109,800MSRP
Overview
Overview
OverviewShop Now
2022 Nissan Altima
$24,900MSRP
Overview
Overview
OverviewShop Now

Overview

MSRP
$109,800
$24,900
Listings

Ratings & Reviews

User reviews
5.0
4.9
Expert reviews

7.5 out of 10

Read full review

7.5 out of 10

Read full review
Pros & cons
Pros
  • Powerful engine
  • Comfortable
  • Impressive technology
Cons
  • High price
Pros
  • Multiple powertrain options
  • Stylish design
  • Standard advanced safety features
Cons
  • Underwhelming base engine
  • All-wheel drive not available with VC-Turbo engine
  • No hybrid option
Summary

The S-Class not only sits at the top of the Mercedes hierarchy in price and prestige, but it has also long served as a technological showcase. In the press release for the redesigned 2021 S-Class, Mercedes repeatedly noted the innovations—from anti-lock brakes to airbags—that were introduced on the big sedan and eventually trickled down to mainstream vehicles.

With the previous generation dating back to the 2014 model year (with a significant update for 2018), the Mercedes-Benz S-Class was in need of an update to maintain that status, and to keep pace with other full-size luxury sedans like the Audi A8, BMW 7 Series, and Lexus LS. To do that, the new S-Class gets a more sophisticated infotainment system, new powertrains, and more aerodynamic bodywork, among other features.

The 2021 S-Class launches in two configurations, both with 4Matic all-wheel drive (AWD) and EQ Boost mild-hybrid systems. The S500 4Matic has a six-cylinder engine, while the S580 4Matic has a V8. We spent a few days with the Mercedes-Benz S580 for this review. A Mercedes-Maybach S680 4Matic version will follow in the first half of 2022, and you can expect a new AMG performance version sometime in the future as well.

The Nissan Altima offers buyers a wide range of choices with two engines, front-wheel drive (FWD) or all-wheel drive (AWD), and five trim levels. But in a crowded midsize sedan segment that includes the ubiquitous Toyota Camry and the Honda Accord—not to mention a handful of other competent entries—the Altima has its work cut out for it. For 2022, Nissan tweaks the Altima's packaging, expanding the availability of the sporty Midnight Edition option package to include the SR trim with the base 2.5-liter four-cylinder engine.
Video
No video found

Popular Features & Specs

Engine
3.0L 429 hp I6
2.5L 188 hp I4
Drive Train
AWD
FWD
Seating Capacity
5
5
Horsepower
429 hp @ 6100 rpm
188 hp @ 6000 rpm
MPG City
20
28
MPG Highway
29
39
Look and feel
2021 Mercedes-Benz S-Class
7/10
2022 Nissan Altima
8/10

The 2021 Mercedes-Benz S-Class retained a familiar exterior design, but with subtle aerodynamic improvements, boasting a drag coefficient of 0.22. It was slightly larger than its predecessor, with a longer wheelbase and increased height and width. The car's size was imposing, complemented by the classic Mercedes hood ornament and grille. Standard 19-inch wheels could be upgraded to 20-inch or 21-inch options, with the 20-inch wheels filling the wheel wells nicely.

Inside, the S-Class focused on a minimalist design centered around an infotainment touchscreen and digital instrument cluster. Mercedes eliminated many traditional controls, opting for a cleaner look with rectangular air vents. The interior featured extensive ambient lighting with 250 LED elements and 64 color options. High-quality materials like Nappa leather and open-pore wood trim were standard, though the piano-black trim was prone to smudging and reflections.

The 2022 Nissan Altima evolved significantly from its earlier generations, adopting a sportier look with a low, wide stance and a "floating" roofline. The car was available in five trim levels: S, SV, SR, SL, and Platinum. The Midnight Edition package added gloss black accents, 19-inch wheels, and other sporty features, enhancing the Altima's already dynamic appearance.

Inside, the Altima offered comfortable Zero Gravity front seats and a well-organized instrument panel. Higher trims featured premium materials, while lower trims were less luxurious. The car's dimensions placed it in the middle of its segment, with a 15.4 cubic foot trunk and a 16.2-gallon fuel tank. However, the high rear shelf and sloping roofline compromised rear visibility, and the trunk's metal bar supports could crush items when closing the lid.

Performance
2021 Mercedes-Benz S-Class
9/10
2022 Nissan Altima
7/10

The 2021 Mercedes-Benz S-Class offered two engine options: a 3.0-liter turbocharged inline-six with 429 horsepower and 384 pound-feet of torque in the S500 4Matic, and a 4.0-liter twin-turbo V8 with 496 hp and 516 lb-ft in the S580 4Matic. Both engines featured EQ Boost, a mild-hybrid system adding 21 hp and 184 lb-ft for short bursts. The S500 accelerated from 0 to 60 mph in 4.8 seconds, while the S580 did it in 4.4 seconds, both with a top speed of 130 mph.

The S-Class came with standard air suspension and an optional E-Active Body Control system. It was the first S-Class with rear-wheel steering, reducing the turning circle by seven feet. The S580 provided a fast and comfortable ride, with precise steering and minimal body roll in Sport and Sport+ modes. However, there was noticeable wind noise at highway speeds.

The 2022 Nissan Altima offered two four-cylinder engines: a 2.5-liter unit with 188 horsepower and 180 pound-feet of torque, and a 2.0-liter variable-compression turbo (VC-Turbo) with 248 hp and 273 lb-ft. The base engine was available with FWD or AWD, while the VC-Turbo was only available on the SR trim with FWD. All Altimas used a CVT, with paddle shifters on the SR trim.

The VC-Turbo engine could change its compression ratio for performance or efficiency, offering V6-like power with four-cylinder efficiency. However, it wasn't available with AWD. The base 2.5-liter engine provided mediocre acceleration and noticeable engine noise, but the Altima's suspension delivered a smooth, composed ride. The cabin was quiet, with minimal bumps and vibrations.

Form and function
2021 Mercedes-Benz S-Class
8/10
2022 Nissan Altima
6/10

The 2021 S-Class offered more front and rear headroom and rear legroom than its predecessor, with segment-leading shoulder room. Cargo space increased to 12.9 cubic feet, though it was still less than other luxury sedans. The power-adjustable front seats had 19 motors, heating, ventilation, and massage functions, with tiny pillows on the headrests. The center console featured a large storage bin, wireless phone charger, and cupholders, while rear passengers had their own console and climate controls.

The 2022 Altima provided comfortable seating for four, with easy-to-use controls and a decent-sized trunk. Its dimensions were average for the segment, with a 15.4 cubic foot trunk and a 16.2-gallon fuel tank. However, the high rear shelf and sloping roofline compromised rear visibility, and the trunk's metal bar supports could crush items when closing the lid.

Technology
2021 Mercedes-Benz S-Class
9/10
2022 Nissan Altima
8/10

The 2021 S-Class featured a 12.3-inch digital instrument cluster and 12.8-inch OLED central touchscreen, with wireless Apple CarPlay and Android Auto, and six USB ports. A 30-speaker Burmester audio system and rear-seat infotainment setup with 11.6-inch touchscreens were available. The updated MBUX system had 50% more computing power and relied more on the touchscreen. The S-Class also had an augmented-reality head-up display and biometric or facial recognition for personal profiles.

The 2022 Altima S had a 5-inch multi-function display and a 7-inch color touchscreen with Bluetooth, voice recognition, and a single USB port. Higher trims featured a 7-inch advanced drive-assist display and an 8-inch touchscreen with wired Apple CarPlay and Android Auto. The SL trim added a nine-speaker Bose audio system, navigation, and remote engine start. Active noise cancellation and ProPilot Assist were available on higher trims.

Safety
2021 Mercedes-Benz S-Class
7/10
2022 Nissan Altima
9/10

The 2021 S-Class had not been crash-tested by NHTSA or IIHS. It featured a rear-passenger airbag, adaptive cruise control, automated lane centering, automatic emergency braking, forward-collision warning, blind-spot monitoring, lane-keep assist, lane-change assist, traffic-sign recognition, driver-attention monitor, and a 360-degree camera system. Mercedes claimed improvements in traffic-sign recognition and lane-keep assist, with capacitive sensors in the steering wheel.

The 2022 Altima had standard automatic emergency braking, lane-departure warning, forward-collision warning, automatic high-beam headlights, driver-attention warning, Rear View Monitor, rear door alert, and hill-start assist. Safety Shield 360 added rear automatic braking, blind-spot warning, rear cross-traffic warning, and a rear sonar system. The Altima received five stars from NHTSA and a "Top Safety Pick+" designation from IIHS.

CarGurus highlights

Winning Vehicle Image

According to CarGurus experts, the overall rating for the 2021 Mercedes-Benz S-Class is 7.5 out of 10, while the 2022 Nissan Altima scores 7.5 out of 10. Both cars offer unique strengths, but the final recommendation depends on your priorities. If you seek luxury, advanced technology, and a powerful engine, the S-Class is the better choice. However, if you need a reliable, well-rounded midsize sedan with good safety ratings and advanced driver-assist features, the Altima is a solid option.

CarGurus highlights

Winning Vehicle Image

According to CarGurus experts, the overall rating for the 2021 Mercedes-Benz S-Class is 7.5 out of 10, while the 2022 Nissan Altima scores 7.5 out of 10. Both cars offer unique strengths, but the final recommendation depends on your priorities. If you seek luxury, advanced technology, and a powerful engine, the S-Class is the better choice. However, if you need a reliable, well-rounded midsize sedan with good safety ratings and advanced driver-assist features, the Altima is a solid option.

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By: CarGurus + AI

At CarGurus, our team of experienced automotive writers remain at the heart of our content operation, conducting hands-on car tests and writing insightful guides that are backed by years of industry experience. To complement this, we are harnessing AI to make our content offering more diverse and more helpful to shoppers than ever. To achieve this, our AI systems are based exclusively on CarGurus content, ratings and data, so that what we produce is both unique to CarGurus, and uniquely helpful to car shoppers.

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