2021 Mercedes-Benz S-Class vs 2022 Nissan Altima
Overview | |
MSRP$109,800 | MSRP$24,900 |
Listings262 | Listings2464 |
Ratings & Reviews | |
User Reviews | User Reviews |
Expert reviews7.5 out of 10 | Expert reviews7.5 out of 10 |
Pros
| Pros
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2021 Mercedes-Benz S-Class Reviews SummaryThe S-Class not only sits at the top of the Mercedes hierarchy in price and prestige, but it has also long served as a technological showcase. In the press release for the redesigned 2021 S-Class, Mercedes repeatedly noted the innovations—from anti-lock brakes to airbags—that were introduced on the big sedan and eventually trickled down to mainstream vehicles. With the previous generation dating back to the 2014 model year (with a significant update for 2018), the Mercedes-Benz S-Class was in need of an update to maintain that status, and to keep pace with other full-size luxury sedans like the Audi A8, BMW 7 Series, and Lexus LS. To do that, the new S-Class gets a more sophisticated infotainment system, new powertrains, and more aerodynamic bodywork, among other features. The 2021 S-Class launches in two configurations, both with 4Matic all-wheel drive (AWD) and EQ Boost mild-hybrid systems. The S500 4Matic has a six-cylinder engine, while the S580 4Matic has a V8. We spent a few days with the Mercedes-Benz S580 for this review. A Mercedes-Maybach S680 4Matic version will follow in the first half of 2022, and you can expect a new AMG performance version sometime in the future as well. | |
2022 Nissan Altima Reviews SummaryThe Nissan Altima offers buyers a wide range of choices with two engines, front-wheel drive (FWD) or all-wheel drive (AWD), and five trim levels. But in a crowded midsize sedan segment that includes the ubiquitous Toyota Camry and the Honda Accord—not to mention a handful of other competent entries—the Altima has its work cut out for it. For 2022, Nissan tweaks the Altima's packaging, expanding the availability of the sporty Midnight Edition option package to include the SR trim with the base 2.5-liter four-cylinder engine. | |
No video found | |
Popular Features & Specs | |
Engine3.0L 429 hp I6 | Engine2.5L 188 hp I4 |
Drive TrainAWD | Drive TrainFWD |
Seating Capacity5 | Seating Capacity5 |
Horsepower429 hp @ 6100 rpm | Horsepower188 hp @ 6000 rpm |
MPG City20 | MPG City28 |
MPG Highway29 | MPG Highway39 |
Engine | |
Engine Name3.0L 429 hp I6 | Engine Name2.5L 188 hp I4 |
Torque384 lb-ft @ 1800 rpm | Torque180 lb-ft @ 3600 rpm |
Horsepower429 hp @ 6100 rpm | Horsepower188 hp @ 6000 rpm |
DrivetrainAWD | DrivetrainFWD |
Fuel Economy | |
MPG City20 | MPG City28 |
MPG Highway29 | MPG Highway39 |
Interior | |
Leather SeatsOptional | Leather Seats |
Seating Capacity5 | Seating Capacity5 |
Key Features | |
Navigation SystemOptional | Navigation System |
Sunroof/MoonroofOptional | Sunroof/Moonroof |
Safety | |
Front Crash Overall | Front Crash Overall4 |
Side Crash Overall | Side Crash Overall5 |
Dimensions & Capacity | |
Cargo Space12.9 cu ft | Cargo Space15.4 cu ft |
Curb Weight4740 lbs | Curb Weight3244 lbs |
Height59.2 in | Height56.7 in |
Length208.2 in | Length192.9 in |
Width83.0 in | Width72.9 in |
Wheelbase126.6 in | Wheelbase111.2 in |
Maximum Payload | Maximum Payload1084 lbs |
Number of doors4 | Number of doors4 |
Overview | ||
MSRP | $109,800 | $24,900 |
Listings | ||
Ratings & Reviews | ||
User reviews | ||
Expert reviews | 7.5 out of 10Read full review | 7.5 out of 10Read full review |
Pros & cons | Pros
| Pros
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Summary | The S-Class not only sits at the top of the Mercedes hierarchy in price and prestige, but it has also long served as a technological showcase. In the press release for the redesigned 2021 S-Class, Mercedes repeatedly noted the innovations—from anti-lock brakes to airbags—that were introduced on the big sedan and eventually trickled down to mainstream vehicles. With the previous generation dating back to the 2014 model year (with a significant update for 2018), the Mercedes-Benz S-Class was in need of an update to maintain that status, and to keep pace with other full-size luxury sedans like the Audi A8, BMW 7 Series, and Lexus LS. To do that, the new S-Class gets a more sophisticated infotainment system, new powertrains, and more aerodynamic bodywork, among other features. The 2021 S-Class launches in two configurations, both with 4Matic all-wheel drive (AWD) and EQ Boost mild-hybrid systems. The S500 4Matic has a six-cylinder engine, while the S580 4Matic has a V8. We spent a few days with the Mercedes-Benz S580 for this review. A Mercedes-Maybach S680 4Matic version will follow in the first half of 2022, and you can expect a new AMG performance version sometime in the future as well. | The Nissan Altima offers buyers a wide range of choices with two engines, front-wheel drive (FWD) or all-wheel drive (AWD), and five trim levels. But in a crowded midsize sedan segment that includes the ubiquitous Toyota Camry and the Honda Accord—not to mention a handful of other competent entries—the Altima has its work cut out for it. For 2022, Nissan tweaks the Altima's packaging, expanding the availability of the sporty Midnight Edition option package to include the SR trim with the base 2.5-liter four-cylinder engine. |
Video | No video found | |
Popular Features & Specs | ||
Engine | 3.0L 429 hp I6 | 2.5L 188 hp I4 |
Drive Train | AWD | FWD |
Seating Capacity | 5 | 5 |
Horsepower | 429 hp @ 6100 rpm | 188 hp @ 6000 rpm |
MPG City | 20 | 28 |
MPG Highway | 29 | 39 |
Engine | ||
Engine Name | 3.0L 429 hp I6 | 2.5L 188 hp I4 |
Torque | 384 lb-ft @ 1800 rpm | 180 lb-ft @ 3600 rpm |
Horsepower | 429 hp @ 6100 rpm | 188 hp @ 6000 rpm |
Drivetrain | AWD | FWD |
Fuel Economy | ||
MPG City | 20 | 28 |
MPG Highway | 29 | 39 |
Interior | ||
Leather Seats | Optional | |
Seating Capacity | 5 | 5 |
Key Features | ||
Navigation System | Optional | |
Sunroof/Moonroof | Optional | |
Safety | ||
Front Crash Overall | 4 | |
Side Crash Overall | 5 | |
Dimensions & Capacity | ||
Cargo Space | 12.9 cu ft | 15.4 cu ft |
Curb Weight | 4740 lbs | 3244 lbs |
Height | 59.2 in | 56.7 in |
Length | 208.2 in | 192.9 in |
Width | 83.0 in | 72.9 in |
Wheelbase | 126.6 in | 111.2 in |
Maximum Payload | 1084 lbs | |
Number of doors | 4 | 4 |
The 2021 Mercedes-Benz S-Class retained a familiar exterior design, but with subtle aerodynamic improvements, boasting a drag coefficient of 0.22. It was slightly larger than its predecessor, with a longer wheelbase and increased height and width. The car's size was imposing, complemented by the classic Mercedes hood ornament and grille. Standard 19-inch wheels could be upgraded to 20-inch or 21-inch options, with the 20-inch wheels filling the wheel wells nicely.
Inside, the S-Class focused on a minimalist design centered around an infotainment touchscreen and digital instrument cluster. Mercedes eliminated many traditional controls, opting for a cleaner look with rectangular air vents. The interior featured extensive ambient lighting with 250 LED elements and 64 color options. High-quality materials like Nappa leather and open-pore wood trim were standard, though the piano-black trim was prone to smudging and reflections.
The 2022 Nissan Altima evolved significantly from its earlier generations, adopting a sportier look with a low, wide stance and a "floating" roofline. The car was available in five trim levels: S, SV, SR, SL, and Platinum. The Midnight Edition package added gloss black accents, 19-inch wheels, and other sporty features, enhancing the Altima's already dynamic appearance.
Inside, the Altima offered comfortable Zero Gravity front seats and a well-organized instrument panel. Higher trims featured premium materials, while lower trims were less luxurious. The car's dimensions placed it in the middle of its segment, with a 15.4 cubic foot trunk and a 16.2-gallon fuel tank. However, the high rear shelf and sloping roofline compromised rear visibility, and the trunk's metal bar supports could crush items when closing the lid.
The 2021 Mercedes-Benz S-Class offered two engine options: a 3.0-liter turbocharged inline-six with 429 horsepower and 384 pound-feet of torque in the S500 4Matic, and a 4.0-liter twin-turbo V8 with 496 hp and 516 lb-ft in the S580 4Matic. Both engines featured EQ Boost, a mild-hybrid system adding 21 hp and 184 lb-ft for short bursts. The S500 accelerated from 0 to 60 mph in 4.8 seconds, while the S580 did it in 4.4 seconds, both with a top speed of 130 mph.
The S-Class came with standard air suspension and an optional E-Active Body Control system. It was the first S-Class with rear-wheel steering, reducing the turning circle by seven feet. The S580 provided a fast and comfortable ride, with precise steering and minimal body roll in Sport and Sport+ modes. However, there was noticeable wind noise at highway speeds.
The 2022 Nissan Altima offered two four-cylinder engines: a 2.5-liter unit with 188 horsepower and 180 pound-feet of torque, and a 2.0-liter variable-compression turbo (VC-Turbo) with 248 hp and 273 lb-ft. The base engine was available with FWD or AWD, while the VC-Turbo was only available on the SR trim with FWD. All Altimas used a CVT, with paddle shifters on the SR trim.
The VC-Turbo engine could change its compression ratio for performance or efficiency, offering V6-like power with four-cylinder efficiency. However, it wasn't available with AWD. The base 2.5-liter engine provided mediocre acceleration and noticeable engine noise, but the Altima's suspension delivered a smooth, composed ride. The cabin was quiet, with minimal bumps and vibrations.
The 2021 S-Class offered more front and rear headroom and rear legroom than its predecessor, with segment-leading shoulder room. Cargo space increased to 12.9 cubic feet, though it was still less than other luxury sedans. The power-adjustable front seats had 19 motors, heating, ventilation, and massage functions, with tiny pillows on the headrests. The center console featured a large storage bin, wireless phone charger, and cupholders, while rear passengers had their own console and climate controls.
The 2022 Altima provided comfortable seating for four, with easy-to-use controls and a decent-sized trunk. Its dimensions were average for the segment, with a 15.4 cubic foot trunk and a 16.2-gallon fuel tank. However, the high rear shelf and sloping roofline compromised rear visibility, and the trunk's metal bar supports could crush items when closing the lid.
The 2021 S-Class featured a 12.3-inch digital instrument cluster and 12.8-inch OLED central touchscreen, with wireless Apple CarPlay and Android Auto, and six USB ports. A 30-speaker Burmester audio system and rear-seat infotainment setup with 11.6-inch touchscreens were available. The updated MBUX system had 50% more computing power and relied more on the touchscreen. The S-Class also had an augmented-reality head-up display and biometric or facial recognition for personal profiles.
The 2022 Altima S had a 5-inch multi-function display and a 7-inch color touchscreen with Bluetooth, voice recognition, and a single USB port. Higher trims featured a 7-inch advanced drive-assist display and an 8-inch touchscreen with wired Apple CarPlay and Android Auto. The SL trim added a nine-speaker Bose audio system, navigation, and remote engine start. Active noise cancellation and ProPilot Assist were available on higher trims.
The 2021 S-Class had not been crash-tested by NHTSA or IIHS. It featured a rear-passenger airbag, adaptive cruise control, automated lane centering, automatic emergency braking, forward-collision warning, blind-spot monitoring, lane-keep assist, lane-change assist, traffic-sign recognition, driver-attention monitor, and a 360-degree camera system. Mercedes claimed improvements in traffic-sign recognition and lane-keep assist, with capacitive sensors in the steering wheel.
The 2022 Altima had standard automatic emergency braking, lane-departure warning, forward-collision warning, automatic high-beam headlights, driver-attention warning, Rear View Monitor, rear door alert, and hill-start assist. Safety Shield 360 added rear automatic braking, blind-spot warning, rear cross-traffic warning, and a rear sonar system. The Altima received five stars from NHTSA and a "Top Safety Pick+" designation from IIHS.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Mercedes-Benz S-Class is 7.5 out of 10, while the 2022 Nissan Altima scores 7.5 out of 10. Both cars offer unique strengths, but the final recommendation depends on your priorities. If you seek luxury, advanced technology, and a powerful engine, the S-Class is the better choice. However, if you need a reliable, well-rounded midsize sedan with good safety ratings and advanced driver-assist features, the Altima is a solid option.
Choose the 2021 Mercedes-Benz S-Class if:
- You prioritize luxury and advanced technology features.
- You want a powerful engine with a smooth, comfortable ride.
- You value a spacious, high-quality interior with extensive customization options.
Choose the 2022 Nissan Altima if:
- You need a reliable, well-rounded midsize sedan with good safety ratings.
- You want a car with advanced driver-assist features at a reasonable price.
- You prefer a sporty design with practical interior space and comfort.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Mercedes-Benz S-Class is 7.5 out of 10, while the 2022 Nissan Altima scores 7.5 out of 10. Both cars offer unique strengths, but the final recommendation depends on your priorities. If you seek luxury, advanced technology, and a powerful engine, the S-Class is the better choice. However, if you need a reliable, well-rounded midsize sedan with good safety ratings and advanced driver-assist features, the Altima is a solid option.
Choose the 2021 Mercedes-Benz S-Class if:
Shop Now- You prioritize luxury and advanced technology features.
- You want a powerful engine with a smooth, comfortable ride.
- You value a spacious, high-quality interior with extensive customization options.
Choose the 2022 Nissan Altima if:
Shop Now- You need a reliable, well-rounded midsize sedan with good safety ratings.
- You want a car with advanced driver-assist features at a reasonable price.
- You prefer a sporty design with practical interior space and comfort.

By: CarGurus + AI
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